Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 10 Researches
8.1
USERS' SCORE
Moderately Good
Based on 25 Reviews
7.8
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Calcium (from Aquamin®)
80 mg
6%
UC-II® Standardized Chicken Cartilage(Providing 10 mg Total Collagen, including Undenatured Type II Collagen)
40 mg
†
Aquamin® (Seaweed Derived Minerals) (Lithothamnium spp.) (Whole Plant)
250 mg
†
Top Medical Research Studies
8
We investigated the effects of GSZD, a traditional decoction, on bone erosion in a rat model of rheumatoid arthritis. Fifty rats were divided into control and treatment groups. Over 21 days, those receiving GSZD showed improved signs of inflammation and reduced joint damage compared to controls.
Specifically, GSZD lowered osteoclast numbers and enhanced protective factors, indicating its potential as a treatment option for rheumatoid arthritis. This study suggests GSZD could serve as a valuable supplement in managing RA symptoms.
Specifically, GSZD lowered osteoclast numbers and enhanced protective factors, indicating its potential as a treatment option for rheumatoid arthritis. This study suggests GSZD could serve as a valuable supplement in managing RA symptoms.
Read More
8
We explored the potential of liposome/gold hybrid nanoparticles combined with Coenzyme Q10 (LGNP-CoQ10) as a treatment for rheumatoid arthritis. In a study involving mice with collagen-induced arthritis, we administered LGNP-CoQ10 for 10 weeks and assessed its effects on joint inflammation.
Our findings revealed a significant reduction in pro-inflammatory cytokines and specific immune cells linked to inflammation. We also observed decreased levels of IL-17 in treated human cells. These results indicate that LGNP-CoQ10 could be a promising therapeutic option for managing rheumatoid arthritis.
Our findings revealed a significant reduction in pro-inflammatory cytokines and specific immune cells linked to inflammation. We also observed decreased levels of IL-17 in treated human cells. These results indicate that LGNP-CoQ10 could be a promising therapeutic option for managing rheumatoid arthritis.
Read More
8
This study looked into whether PC1 could help manage rheumatoid arthritis (RA) using a mouse model. After immunization with collagen and other agents, mice received daily doses of PC1.
We noticed that those treated with PC1 experienced significantly less inflammation in their paws and showed reduced joint damage. Additionally, their blood tests revealed lower levels of certain inflammatory markers and higher anti-inflammatory cytokines.
These findings suggest that early use of PC1 might be a beneficial approach in treating RA.
We noticed that those treated with PC1 experienced significantly less inflammation in their paws and showed reduced joint damage. Additionally, their blood tests revealed lower levels of certain inflammatory markers and higher anti-inflammatory cytokines.
These findings suggest that early use of PC1 might be a beneficial approach in treating RA.
Read More
Most Useful Reviews
7.5
Knees stopped hurting
122 people found this helpful
I began taking collagen on my rheumatologist's advice due to my rheumatoid arthritis. After 10 days, my knees stopped hurting and my hands felt easier. While miracles don’t happen and damaged joints can't be restored, at least my mobility has improved. If you have joint pain, don’t delay treatment! I highly recommend it!
Read More
10
Miracle supplement
7 people found this helpful
It works! I was suffering from severe pain and tested positive for rheumatoid arthritis. After using UC 2, I feel fantastic. It truly is a miracle.
Read More
9
Knee function improved
My wife has rheumatoid arthritis. After taking one package, her knee joint function noticeably improved. We’ve decided to continue taking it long-term, as this improvement gives me hope!
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 10 Researches
8.1
- All Researches
9
We examined the effects of salvianolic acid B (SB), a natural compound from the plant Radix Salvia miltiorrhiza, on rheumatoid arthritis in rats.
The study revealed that SB significantly reduced paw swelling and inflammatory markers in rats with collagen-induced arthritis.
By administering SB, we observed improvements in arthritis scores and decreased levels of harmful inflammatory cytokines, indicating its potential as an effective treatment.
Overall, SB demonstrates promise in alleviating symptoms of rheumatoid arthritis by reducing inflammation and oxidative stress.
The study revealed that SB significantly reduced paw swelling and inflammatory markers in rats with collagen-induced arthritis.
By administering SB, we observed improvements in arthritis scores and decreased levels of harmful inflammatory cytokines, indicating its potential as an effective treatment.
Overall, SB demonstrates promise in alleviating symptoms of rheumatoid arthritis by reducing inflammation and oxidative stress.
Read More
9
We evaluated how Euglena gracilis Z and its carbohydrate paramylon can alleviate symptoms of rheumatoid arthritis. In our study with mice, we noted significant reductions in arthritis signs and inflammation after treatment.
Both substances appeared to lower critical immune markers like IL-17 and IL-6, indicating a positive effect on the immune system. The E. gracilis Z group showed outstanding improvements, with no signs of edema or cartilage destruction.
Overall, we found that both E. gracilis Z and paramylon could effectively relieve arthritis symptoms.
Both substances appeared to lower critical immune markers like IL-17 and IL-6, indicating a positive effect on the immune system. The E. gracilis Z group showed outstanding improvements, with no signs of edema or cartilage destruction.
Overall, we found that both E. gracilis Z and paramylon could effectively relieve arthritis symptoms.
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8
We investigated the effects of GSZD, a traditional decoction, on bone erosion in a rat model of rheumatoid arthritis. Fifty rats were divided into control and treatment groups. Over 21 days, those receiving GSZD showed improved signs of inflammation and reduced joint damage compared to controls.
Specifically, GSZD lowered osteoclast numbers and enhanced protective factors, indicating its potential as a treatment option for rheumatoid arthritis. This study suggests GSZD could serve as a valuable supplement in managing RA symptoms.
Specifically, GSZD lowered osteoclast numbers and enhanced protective factors, indicating its potential as a treatment option for rheumatoid arthritis. This study suggests GSZD could serve as a valuable supplement in managing RA symptoms.
Read More
We explored how two derivatives of oleuropein, a natural compound from olive trees, affect joint inflammation in mice with collagen-induced arthritis. Mice were given diets enriched with oleuropein or its derivative for six weeks before inducing arthritis.
Both compounds showed promising effects in reducing joint damage and markers of inflammation, although there were no significant differences between them. This suggests that dietary oleuropein may offer a potential new approach to support joint health for those at risk of rheumatoid arthritis.
Both compounds showed promising effects in reducing joint damage and markers of inflammation, although there were no significant differences between them. This suggests that dietary oleuropein may offer a potential new approach to support joint health for those at risk of rheumatoid arthritis.
Read More
8
We explored the potential of liposome/gold hybrid nanoparticles combined with Coenzyme Q10 (LGNP-CoQ10) as a treatment for rheumatoid arthritis. In a study involving mice with collagen-induced arthritis, we administered LGNP-CoQ10 for 10 weeks and assessed its effects on joint inflammation.
Our findings revealed a significant reduction in pro-inflammatory cytokines and specific immune cells linked to inflammation. We also observed decreased levels of IL-17 in treated human cells. These results indicate that LGNP-CoQ10 could be a promising therapeutic option for managing rheumatoid arthritis.
Our findings revealed a significant reduction in pro-inflammatory cytokines and specific immune cells linked to inflammation. We also observed decreased levels of IL-17 in treated human cells. These results indicate that LGNP-CoQ10 could be a promising therapeutic option for managing rheumatoid arthritis.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 25 Reviews
7.8
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Knees stopped hurting
122 people found this helpful
I began taking collagen on my rheumatologist's advice due to my rheumatoid arthritis. After 10 days, my knees stopped hurting and my hands felt easier. While miracles don’t happen and damaged joints can't be restored, at least my mobility has improved. If you have joint pain, don’t delay treatment! I highly recommend it!
Read More
10
Miracle supplement
7 people found this helpful
It works! I was suffering from severe pain and tested positive for rheumatoid arthritis. After using UC 2, I feel fantastic. It truly is a miracle.
Read More
9
Knee function improved
My wife has rheumatoid arthritis. After taking one package, her knee joint function noticeably improved. We’ve decided to continue taking it long-term, as this improvement gives me hope!
Read More
9
Very good results
After being prescribed this for her rheumatoid arthritis, my mother has been drinking it periodically for six months. She experiences greatly reduced swelling in the morning, and her immobility has improved.
Read More
9
Regained flexibility
The transport, packaging, and timing of the product were flawless. Having rheumatoid arthritis, I've regained flexibility in my affected joints—my pain has reduced and there's no longer synovial swelling, thanks to UC-II along with sulfur MSM and quinton water.
Read More
Frequently Asked Questions
7.5
Knees stopped hurting
122 people found this helpful
I began taking collagen on my rheumatologist's advice due to my rheumatoid arthritis. After 10 days, my knees stopped hurting and my hands felt easier. While miracles don’t happen and damaged joints can't be restored, at least my mobility has improved. If you have joint pain, don’t delay treatment! I highly recommend it!
9
Relief after a month
3 people found this helpful
I have rheumatoid arthritis, and after a month of using this collagen, my joints felt relief. I strongly advise others to try it!
9
Significant improvement
I take the supplement periodically for my rheumatoid arthritis. After three months of use, followed by a month off, I noticed significant improvement in my condition and would recommend it to others experiencing similar challenges.
9
Very good results
After being prescribed this for her rheumatoid arthritis, my mother has been drinking it periodically for six months. She experiences greatly reduced swelling in the morning, and her immobility has improved.
9
Knee function improved
My wife has rheumatoid arthritis. After taking one package, her knee joint function noticeably improved. We’ve decided to continue taking it long-term, as this improvement gives me hope!
9
Regained flexibility
The transport, packaging, and timing of the product were flawless. Having rheumatoid arthritis, I've regained flexibility in my affected joints—my pain has reduced and there's no longer synovial swelling, thanks to UC-II along with sulfur MSM and quinton water.
7.5
Essential for pain relief
This product is essential for reducing the pain of rheumatoid arthritis. The combination of high-dose omega 3, turmeric, boswellia, MSM, and hyaluronic acid does the job after several weeks and is much cheaper than other brands.
6
Pain reduction
I have rheumatoid arthritis and need to support my joints, especially during the colder months when they become inflamed. I take UC-II for at least six months, ensuring not to combine it with collagen types 1 and 3. After a week of use, I've noticed a reduction in pain and some decrease in inflammation, although I understand more time may be needed.
8
We investigated the effects of GSZD, a traditional decoction, on bone erosion in a rat model of rheumatoid arthritis. Fifty rats were divided into control and treatment groups. Over 21 days, those receiving GSZD showed improved signs of inflammation and reduced joint damage compared to controls.
Specifically, GSZD lowered osteoclast numbers and enhanced protective factors, indicating its potential as a treatment option for rheumatoid arthritis. This study suggests GSZD could serve as a valuable supplement in managing RA symptoms.
Specifically, GSZD lowered osteoclast numbers and enhanced protective factors, indicating its potential as a treatment option for rheumatoid arthritis. This study suggests GSZD could serve as a valuable supplement in managing RA symptoms.
We explored how two derivatives of oleuropein, a natural compound from olive trees, affect joint inflammation in mice with collagen-induced arthritis. Mice were given diets enriched with oleuropein or its derivative for six weeks before inducing arthritis.
Both compounds showed promising effects in reducing joint damage and markers of inflammation, although there were no significant differences between them. This suggests that dietary oleuropein may offer a potential new approach to support joint health for those at risk of rheumatoid arthritis.
Both compounds showed promising effects in reducing joint damage and markers of inflammation, although there were no significant differences between them. This suggests that dietary oleuropein may offer a potential new approach to support joint health for those at risk of rheumatoid arthritis.
8
We explored the potential of liposome/gold hybrid nanoparticles combined with Coenzyme Q10 (LGNP-CoQ10) as a treatment for rheumatoid arthritis. In a study involving mice with collagen-induced arthritis, we administered LGNP-CoQ10 for 10 weeks and assessed its effects on joint inflammation.
Our findings revealed a significant reduction in pro-inflammatory cytokines and specific immune cells linked to inflammation. We also observed decreased levels of IL-17 in treated human cells. These results indicate that LGNP-CoQ10 could be a promising therapeutic option for managing rheumatoid arthritis.
Our findings revealed a significant reduction in pro-inflammatory cytokines and specific immune cells linked to inflammation. We also observed decreased levels of IL-17 in treated human cells. These results indicate that LGNP-CoQ10 could be a promising therapeutic option for managing rheumatoid arthritis.
8
We investigated the impact of mango ginger on collagen-induced arthritis in rats. Twenty-one female Wistar-albino rats were divided into groups, receiving an MG extract after arthritis was induced.
The results revealed that MG significantly reduced inflammatory markers like TNF-α and IL-17 while enhancing levels of beneficial substances such as obestatin. Additionally, MG appeared to mitigate joint inflammation and damage effectively.
These findings suggest mango ginger could potentially be a beneficial treatment for rheumatoid arthritis, showing promise in its anti-inflammatory efforts.
The results revealed that MG significantly reduced inflammatory markers like TNF-α and IL-17 while enhancing levels of beneficial substances such as obestatin. Additionally, MG appeared to mitigate joint inflammation and damage effectively.
These findings suggest mango ginger could potentially be a beneficial treatment for rheumatoid arthritis, showing promise in its anti-inflammatory efforts.
9
We examined the effects of salvianolic acid B (SB), a natural compound from the plant Radix Salvia miltiorrhiza, on rheumatoid arthritis in rats.
The study revealed that SB significantly reduced paw swelling and inflammatory markers in rats with collagen-induced arthritis.
By administering SB, we observed improvements in arthritis scores and decreased levels of harmful inflammatory cytokines, indicating its potential as an effective treatment.
Overall, SB demonstrates promise in alleviating symptoms of rheumatoid arthritis by reducing inflammation and oxidative stress.
The study revealed that SB significantly reduced paw swelling and inflammatory markers in rats with collagen-induced arthritis.
By administering SB, we observed improvements in arthritis scores and decreased levels of harmful inflammatory cytokines, indicating its potential as an effective treatment.
Overall, SB demonstrates promise in alleviating symptoms of rheumatoid arthritis by reducing inflammation and oxidative stress.
7
We aimed to explore the potential benefits of a proprietary supplement containing n-enriched THIAA and undenatured type 2 collagen on joint discomfort in people with arthritis.
Over 12 weeks, 17 adults—some diagnosed with rheumatoid arthritis (RA) and osteoarthritis (OA)—took the supplement and reported their experiences through various questionnaires.
Results indicated that this combination was not only safe to use but also showed promise in alleviating chronic joint pain.
Over 12 weeks, 17 adults—some diagnosed with rheumatoid arthritis (RA) and osteoarthritis (OA)—took the supplement and reported their experiences through various questionnaires.
Results indicated that this combination was not only safe to use but also showed promise in alleviating chronic joint pain.
References
- Wei SJ, Zhang Q, Xiang YJ, Peng LY, Peng W, et al. decoction attenuates bone erosion in rats that have collagen-induced arthritis via modulating NF-κB signalling to suppress osteoclastogenesis. Pharm Biol. 2021;59:262. doi:10.1080/13880209.2021.1876100
- Castejón ML, Alarcón-de-la-Lastra C, Rosillo MÁ, Montoya T, Fernández-Bolaños JG, et al. A New Peracetylated Oleuropein Derivative Ameliorates Joint Inflammation and Destruction in a Murine Collagen-Induced Arthritis Model via Activation of the Nrf-2/Ho-1 Antioxidant Pathway and Suppression of MAPKs and NF-κB Activation. Nutrients. 2021;13. doi:10.3390/nu13020311
- Jhun J, Moon J, Ryu J, Shin Y, Lee S, et al. Liposome/gold hybrid nanoparticle encoded with CoQ10 (LGNP-CoQ10) suppressed rheumatoid arthritis via STAT3/Th17 targeting. PLoS One. 2020;15:e0241080. doi:10.1371/journal.pone.0241080
- Karataş A, Orhan C, Tuzcu M, Şahin N, Özercan İH, et al. Mango ginger (curcuma amada) inhibits collagen-induced arthritis by modulating inflammatory cytokine levels in rats. Turk J Med Sci. 2020;50:2040. doi:10.3906/sag-2004-105
- Esvaran M, Conway PL. PC1 has the Capacity to Attenuate Joint Inflammation in Collagen-Induced Arthritis in DBA/1 Mice. Nutrients. 2019;11. doi:10.3390/nu11040785
- Xia ZB, Yuan YJ, Zhang QH, Li H, Dai JL, et al. Salvianolic Acid B Suppresses Inflammatory Mediator Levels by Downregulating NF-κB in a Rat Model of Rheumatoid Arthritis. Med Sci Monit. 2018;24:2524.
- Hong R, Sur B, Yeom M, Lee B, Kim KS, et al. Anti-inflammatory and anti-arthritic effects of the ethanolic extract of Aralia continentalis Kitag. in IL-1β-stimulated human fibroblast-like synoviocytes and rodent models of polyarthritis and nociception. Phytomedicine. 2018;38:45. doi:10.1016/j.phymed.2017.10.016
- Suzuki K, Nakashima A, Igarashi M, Saito K, Konno M, et al. Euglena gracilis Z and its carbohydrate storage substance relieve arthritis symptoms by modulating Th17 immunity. PLoS One. 2018;13:e0191462. doi:10.1371/journal.pone.0191462
- Olson JM, Haas AW, Lor J, McKee HS, Cook ME. A Comparison of the Anti-Inflammatory Effects of Cis-9, Trans-11 Conjugated Linoleic Acid to Celecoxib in the Collagen-Induced Arthritis Model. Lipids. 2017;52:151. doi:10.1007/s11745-016-4228-8
- Lerman RH, Chang JL, Konda V, Desai A, Montalto MB. Nutritional Approach for Relief of Joint Discomfort: A 12-week, Open-case Series and Illustrative Case Report. Integr Med (Encinitas). 2015;14:52.
